Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome

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Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes.

OBJECTIVE To describe a series of 41 patients with fresh lesions of Sweet syndrome in which the histopathologic study demonstrated an inflammatory infiltrate mostly composed of histiocytoid mononuclear cells. DESIGN Histopathologic, immunohistochemical, and cytogenetic studies of the inflammatory infiltrate in a case series of histiocytoid Sweet syndrome. SETTING University departments of d...

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Sweet syndrome was first described in 1964, at which time it was termed acute febrile neutrophilic dermatosis.1 Up to 20% of patients with Sweet syndrome have an associated malignancy, of whom about 85% have a hematologic disorder.2 The hallmark of Sweet syndrome is a nodular and diffuse dermal infiltrate of neutrophils identified on biopsy.3 The mechanism of the syndrome is not completely unde...

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ژورنال

عنوان ژورنال: JAMA Dermatology

سال: 2017

ISSN: 2168-6068

DOI: 10.1001/jamadermatol.2016.6092